Select Publications: 


1.      Williams, H. L., Gottesman, M. E., & Gautier, J. (2013). The differences between ICL repair during and outside of S phase. Trends in biochemical sciences. doi:10.1016/j.tibs.2013.05.004


2.      Srinivasan, S. V., Dominguez-Sola, D., Wang, L. C., Hyrien, O., & Gautier, J. (2013). Cdc45 is a critical effector of myc-dependent DNA replication stress. Cell reports, 3(5), 1629–1639. doi:10.1016/j.celrep.2013.04.002


3.      Rozier, L., Guo, Y., Peterson, S., Sato, M., Baer, R., Gautier, J., & Mao, Y. (2013). The MRN-CtIP Pathway Is Required for Metaphase Chromosome Alignment. Molecular cell, 49(6), 1097–1107. doi:10.1016/j.molcel.2013.01.023


4.      Peterson, S. E., Li, Y., Wu-Baer, F., Chait, B. T., Baer, R., Yan, H., Gottesman, M. E., et al. (2013). Activation of DSB processing requires phosphorylation of CtIP by ATR. Molecular cell, 49(4), 657–667. doi:10.1016/j.molcel.2012.11.020


5.      Aparicio, T., & Gautier, J. (2012). More tasks for Dna2 in S-phase. Cell cycle (Georgetown, Tex.), 11(23), 4299–4300. doi:10.4161/cc.22807


6.      Williams H., Gottesman M.E. and Gautier J. : (2012) Mechanism of replication-independent interstrand crosslink repair.  Molecular cell. In press.   


7.      Peterson S., Li Y., Chait B., Baer R., Gottesman M. and Gautier J. : (2011) Cdk1 uncouples CtIP-dependent resection and Rad51 filament formation during M-phase double-strand break repair.  J. Cell Biol.   194: 705-720


8.      Ben-Yehoyada M, Wang LC, Kozekov ID, Rizzo CJ, Gottesman ME, Gautier J. Checkpoint signaling from a single DNA interstrand crosslink. Mol Cell. 2009 Sep 11;35(5):704-15. pmid:19748363. PubMed HubMed


9.      Wang LC, Stone S, Hoatlin ME, Gautier J. Fanconi anemia proteins stabilize replication forks. DNA Repair (Amst). 2008 Sep 8. [Epub ahead of print] pmid:18786657. PubMed HubMed


10.    Dupre A, Boyer-Chatenet L, Sattler RM, Modi AP, Lee JH, Nicolette ML, Kopelovich L, Jasin M, Baer R, Paull TT, and Gautier J. A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex. Nat Chem Biol 2008 Feb; 4(2) 119-25. doi:10.1038/nchembio.63 pmid:18176557.PubMed HubMed


11.    Dominguez-Sola D, Ying CY, Grandori C, Ruggiero L, Chen B, Li M, Galloway DA, Gu W, Gautier J, Dalla-Favera R. Non-transcriptional control of DNA replication by c-Myc. Nature. 2007 Jul 26;448(7152):445-51. Epub 2007 Jun 27.pmid:17597761 PubMed HubMed


12.    Greenwood J, Gautier J. XLX is an IAP family member regulated by phosphorylation during meiosis. Cell Death Differ. 2007 Mar;14(3):559-67. Epub 2006 Sep 29. PMID: 17008917 PubMed HubMed


13.    Dupre A, Boyer-Chatenet L, and Gautier J. Two-step activation of ATM by DNA and the Mre11-Rad50-Nbs1 complex. Nat Struct Mol Biol 2006 May; 13(5) 451-7. doi:10.1038/nsmb1090 pmid:16622404. PubMed HubMed


14.    Ying CY, Gautier J. The ATPase activity of MCM2-7 is dispensable for pre-RC assembly but is required for DNA unwinding. EMBO J. 2005 Dec 21;24(24):4334-44. Epub 2005 Nov 24. PMID: 16369567 PubMed HubMed


15.    Di Virgilio M, Gautier J. Repair of double-strand breaks by nonhomologous end joining in the absence of Mre11. J Cell Biol. 2005 Dec 5;171(5):765-71.PubMed HubMed


16.    Yeo W, Gautier J. XNGNR1-dependent neurogenesis mediates early neural cell death. Mech Dev. 2005 May;122(5):635-44. Epub 2005 Jan 8. PubMedHubMed


17.    Shechter D, Gautier J. ATM and ATR check in on origins: a dynamic model for origin selection and activation. Cell Cycle. 2005 Feb;4(2):235-8. Epub 2005 Feb 13. PubMed HubMed


18.    Shechter D, Ying CY, Gautier J. DNA unwinding is an Mcm complex-dependent and ATP hydrolysis-dependent process. J Biol Chem. 2004 Oct 29;279(44):45586-93. Epub 2004 Aug 23. PubMed HubMed


19.    Shechter D, Gautier J. MCM proteins and checkpoint kinases get together at the fork. Proc Natl Acad Sci U S A. 2004 Jul 27;101(30):10845-6. Epub 2004 Jul 19. PubMed HubMed


20.    Shechter D, Costanzo V, Gautier J. ATR and ATM regulate the timing of DNA replication origin firing. Nat Cell Biol. 2004 Jul;6(7):648-55. Epub 2004 Jun 27. PubMed HubMed

Laboratory of Jean Gautier

Columbia University

Department of Genetics and Development

1130 St. Nicholas Avenue, ICRC Room 603A, New York NY 10032


Phone: 212-851-4566

Fax: 212-851-5284