Our Research: 

 

We use Xenopus laevis cell-free extracts to study DNA replication and repair. We are interested in understanding:

 

  • the mechanism of double-strand break resection with a focus on the role of CtIP

  • the mechanism of double strand break repair pathway choice, and its relevance to cancer development 

  • understanding the mechanism by which cMYC regulates DNA replication

  • the molecular mechanism of replication independent repair (RIR) of DNA interstrand crosslinks 

Laboratory of Jean Gautier

Columbia University

Department of Genetics and Development

1130 St. Nicholas Avenue, ICRC Room 603A, New York NY 10032

 

Phone: 212-851-4566

Fax: 212-851-5284

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