Our Research:
We use Xenopus laevis cell-free extracts to study DNA replication and repair. We are interested in understanding:
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the mechanism of double-strand break resection with a focus on the role of CtIP
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the mechanism of double strand break repair pathway choice, and its relevance to cancer development
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understanding the mechanism by which cMYC regulates DNA replication
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the molecular mechanism of replication independent repair (RIR) of DNA interstrand crosslinks